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Small-Cap Biotechs Explode as SPRB Soars 466% in Broad Rally

NYSE | NASDAQ
October 6, 2025 | 9:00pm

Daily Market Recap – October 6, 2025

Introduction

Trading on October 6 saw a broad rally across small- and mid-cap equities, led by clinical-stage biotechs and specialty technology names. Several stocks more than doubled on heightened volume, while established issues such as AMD registered solid gains on heavy activity. Below is a summary of the day’s price action, volumes and percentage changes for 19 notable tickers.

Key Market Data

TickerATTN PriceCurrent PriceVolumePrice Change %
SPRB22.78128.9312,682,159466.10%
SKYE1.541.99999,851,37829.94%
ONMD0.882.2899172,200,629160.28%
AMD184.90206.40164,766,68511.67%
FEMY0.620.816041,910,38231.24%
SOPA1.964.5500101,040,395131.87%
CRML5.8410.641398,498,80382.30%
DFLI1.161.380056,031,50118.46%
LPTX0.500.761568,521,86551.10%
STEX5.156.40004,092,66124.39%
LXEH0.170.91136,103,306440.20%
PALI1.431.900035,384,69532.56%
PSTV0.710.887050,379,49725.00%
ELPW0.310.532113,321,21571.57%
SLDP3.985.810036,436,65545.95%
FLUX3.674.9000898,53333.42%
OMEX2.112.70005,549,15628.18%
CCTG1.181.6900465,67843.51%
APDN4.465.68001,765,41427.33%
Biotech Rally

Biotech Rally by Joseph Chan

Market Analysis

Biotech and small-cap technology issues dominated today’s advance, with half of the sample group trading more than 30% higher. The average percentage gain among these 19 tickers was roughly 82%, driven by multiple double- and triple-digit moves. Unusual volume accompanied most of the eye-popping moves, notably in ONMD, SOPA and CRML, each trading well above 90 million shares.

Larger names also participated in the uptrend. AMD posted an 11.7% gain on 165 million shares, echoing broader semiconductor strength. Mid-caps such as STEX and APDN recorded mid-20% gains, while crossover names in the digital health and loyalty-platform spaces surged on breakout volume.

Notable Movers

Spruce Biosciences (SPRB) led all advancers with a 466% surge to $128.93, following a morning gap above $30 and sustained buying throughout the session. Lixiang Education (LXEH) nearly quadrupled its price, ending at $0.91 after regulatory filings and ADS-ratio news triggered heavy flows. OneMedNet (ONMD) climbed 160% to $2.29 on its Palantir partnership and new equity announcement, with over 172 million shares changing hands.

Society Pass (SOPA) rallied 132% on a strong-buy rating and Nasdaq compliance filing, while Critical Metals (CRML) added 82% on a $35 million PIPE financing and Greenland expansion update. ELPW and LPTX each rose more than 50% on volume in excess of 13 million and 68 million shares, respectively, underscoring the broad strength in micro- and nano-caps.

tl;dr

  • Small-cap biotech and technology names drove the session, with an average gain of 82% across 19 tickers.
  • SPRB (+466%), LXEH (+440%) and ONMD (+160%) posted the largest moves amid news catalysts and heavy volume.
  • Established names like AMD also contributed, up 11.7% on 165 million shares, alongside mid-caps STEX and APDN.
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